The four possible study treatments were t-PA plus DNase, DNase plus placebo, t-PA plus placebo, and double placebo. Placebos were identical in appearance and product packaging to the corresponding energetic drugs. The dose of DNase was 5 mg, and the dose of t-PA was 10 mg. Intrapleural medicines were each given daily for 3 days twice, and each administration was followed by clamping of the drain allowing the study medication to stay in the pleural space for one hour. Outcomes Primary End Point The principal end point was the change in the area of pleural opacity, measured as the %age of the ipsilateral hemithorax occupied by effusion on chest radiography, from day time 1 to time 7. The region of pleural opacity and the region of the ipsilateral hemithorax had been measured digitally by two individual assessors .Wouldn’t it be great if rather than beating on children about screen period we turned screen period into a positive? she said. Fat loss, more activity To carry out the study, researchers merely added to an existing weight loss program that they found to work for both children and parents. They then recruited 75 over weight and obese children from Massachusetts, Texas and Rhode Island who were after that randomly designated to two organizations for a 16-week period. Both of the groups were assigned to take part in the weight management program at a local YMCA and at college, but one of the organizations was also provided an Xbox video game console and a set of active games to play.