At 1 month old, a renal specimen obtained by percutaneous needle biopsy with ultrasonographic guidance revealed globally atrophic glomeruli, focal segmental glomerulosclerosis, diffuse interstitial fibrosis, tubular atrophy, and reduction and immaturity of the tubules . At age 5.5 months, a lung specimen obtained by open biopsy from the middle lobe, which was markedly abnormal on CT, showed hyperinflation and mild-to-moderate simplification of air spaces, suggesting impaired alveolarization or lobular remodeling . Mild reactive changes in the bronchioles included intraluminal mucus stasis, focal neutrophils, and focal bronchiolar fibrosis. The newborn died at the age of 7.5 months during an bout of pulmonary infection.Outcomes Baseline Study and Characteristics Completion We enrolled 198 men in cohort 1 and 202 men in cohort 2 . There have been no significant variations in baseline testosterone amounts among dose groups or between cohorts . Ten males in cohort 1 and 27 in cohort 2 discontinued the analysis before week 8 and were contained in analyses of baseline data just. We conducted a modified intention-to-treat analysis of the rest of the data. In cohort 1, a total of 24 men discontinued participation between weeks 8 and 16, of whom 16 underwent follow-up body-composition and power testing. Four additional participants were later excluded for process violations. In cohort 2, a complete of 17 guys discontinued participation between weeks 8 and 16, of whom 13 underwent follow-up body-composition and strength testing.