Received 400 mg bid or 800 mg bid.
Anadys recently initiated patient dosing in a Phase Ib study of ANA598 in HCV patients Naive genotype 1a and 1b patients ANA598 for three days at doses of 200 mg bid , received 400 mg bid or 800 mg bid. Ten patients in each dose, eight drug and two received placebo have been enrolled. Anadys recently completed dosing study in the Phase I of ANA598 in healthy volunteers.
From complications of HCV.. In addition to the results of the Phase I study in healthy subjects, Anadys will present additional data on the preclinical profile ANA598 at AASLD Meeting on Tuesday, November. ‘studies have shown that studies have shown that combinations of antiviral agents, the HCV polymerase inhibitor ANA598 include the potential viral resistance have overcome ‘in a poster entitled, is Anadys the results of the in vitro studies showing ANA598 synergistically with interferon-alpha, the protease inhibitor telaprevir , and the nucleoside polymerase inhibitor PSI-6130 . These studies also show that ANA598 activity against mutants known resistance to other classes of direct antiviral, including protease inhibitors, nucleoside inhibitors, non-nucleoside analogues that bind confer thumb.Lithium Yang Chiang1, Kate Poole1, Beatriz E. Oliveira2, Neuza Duarte1, Yinth Andrea Bernal sierra1, Leena Bruckner – Tuderman3, Manuel Koch2, Essence Hu1, 4 and Gary R. Lewin1. 5These authors contributed equally to this workOn.
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